The 'Born This Way' singer, who recently launched her own charity foundation and said that she wants to set up an Indian orphanage, will be interviewed by Katie Couric as part of A Very GaGa Thanksgiving.
Broadcaster ABC promised that the 90-minute show will be an intimate look inside the personal life of Lady GaGa.
She will also perform eight songs in front of a group of close friends and family - including latest singles 'Marry the Night', 'You and I' and 'The Edge of Glory' - and will also sing a duet of 'The Lady is a Tramp' with Tony Bennett.
Celebrity Chef Art Smith will also be a special guest on the show, helping Lady GaGa prepare a Thanksgiving feast of deep-fried turkey and waffles for her guests.
Couric said: "We all know Lady GaGa is a phenomenon. This is a chance to see more of who she is beneath the wild costumes and staged musical numbers.
"Lady GaGa as a high school student still bruised by being excluded from the party, Lady GaGa as a devoted daughter and caring sister, Lady GaGa as a 25-year-old woman embracing fame and fortune that seemed to come overnight. She will impress you, delight you and surprise you."
A Very GaGa Thanksgiving will air on November 24 on ABC.
> Lady GaGa makes directorial debut on 'Marry The Night' music video
> Lady GaGa: 'I love Bollywood'