The former heavyweight champ and his family were staying in Sin City over the New Year weekend (31Dec11-01Jan12) when he awoke to see a flashlight and hear rustling in his room.
But before Tyson got a chance to grab the intruder, the man fled, according to TMZ.com.
A spokesman for the hotel tells the website, "We have received a report of an incident that is currently under investigation. As always, guest safety is of the utmost importance."